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“The joy of discovery is certainly the liveliest that the mind of man can ever feel”


- Claude Bernard -


Deng X, Milligan K, Ali-Adeeb R, Shreeves P, Brolo A, Lum JJ, Andrews JL, Jirasek A. Group and Basis Restricted Non-Negative Matrix Factorization and Random Forest for Molecular Histotype Classification and Raman Biomarker Monitoring in Breast Cancer. Appl Spectros. 2021 Aug 6;37028211035398. doi: 10.1177/00037028211035398.

Tessier-Cloutier B, Twa DD, Marzban M, Kalina J, Chun HE, Pavey N, Tanweer Z, Katz RL, Lum JJ, Salina D. The presence of tumour-infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma. J Pathol Clin Res. 2021 Jul;7(4):385-396. doi: 10.1002/cjp2.204. Epub 2021 Mar 4. PMID: 33665979

Klionsky DJ,  et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4rd edition). Autophagy

2021 Jan;17(1):1-382.doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8.


Milligan K, Deng X, Shreeves P, Ali-Adeeb R, Matthews Q, Brolo A, Lum JJ, Andrews JL, Jirasek A. Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells. Sci Rep. 2021 Feb 16;11(1):3853. doi: 10.1038/s41598-021-83343-5. PMID: 33594122

Kilgour MK, MacPherson S, Zacharias LG, Ellis AE, Sheldon RD, Liu EY, Keyes S, Pauly B, Carleton G, Allard B, Smazynski J, Williams KS, Watson PH, Stagg J, Nelson BH, DeBerardinis RJ, Jones RG, Hamilton PT, Lum JJ. 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer. Sci Adv. 2021 Jan 20;7(4):eabe1174. doi: 10.1126/sciadv.abe1174. Print 2021 Jan. PMID: 33523930

Seyfoori A, Barough MS, Amereh M, Jush BK, Lum JJ, Akbari M. Bioengineered tissue models for the development of dynamic immuno-associated tumor models and high-throughput immunotherapy cytotoxicity assays. Drug Discov Today. 2021 Feb;26(2):455-473. doi: 10.1016/j.drudis.2020.11.028. Epub 2020 Nov 27. PMID: 33253917



Deng X, Ali-Adeeb R, Andrews JL, Shreeves P, Lum JJ, Brolo A, Jirasek A. Monitor Ionizing Radiation-Induced Cellular Responses with Raman Spectroscopy, Non-Negative Matrix Factorization, and Non-Negative Least Squares. Appl Spectrosc. 2020 Jun;74(6):701-711. doi: 10.1177/0003702820906221. Epub 2020 Mar 18. PMID: 32098482.


Milosevich N, McFarlane J, Gignac MC, Li J, Brown TM, Wilson CR, Devorkin L, Croft CS, Hof R, Paci I, Lum JJ, Hof F. Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins. Bioorg Med Chem. 2020 Jan 1;28(1):115176. doi: 10.1016/j.bmc.2019.115176. Epub 2019 Nov 9. PMID: 31753799.


Carleton G, Lum JJ. Autophagy metabolically suppresses CD8+ T cell antitumor immunity. Autophagy. 2019 Jun 14:1-2. PubMed PMID: 31170865. 

DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H,Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, MoksaM, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ. Autophagy Regulation of Metabolism Is Required for CD8(+) T Cell Anti-tumor Immunity. Cell Rep. 2019 Apr9;27(2):502-513.e5. PubMed PMID: 30970253.

Vrbik I, Van Nest SJ, Meksiarun P, Loeppky J, Brolo A, Lum JJ, Jirasek A. Haralick texture feature analysis for quantifying radiation response heterogeneity in murine models observed using Raman spectroscopic mapping. PLoS One. 2019 Feb 15;14(2):e0212225. eCollection2019. PubMed PMID: 30768630; PubMed Central PMCID: PMC6377107.



Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018 Jul 27;361(6400):406-411. PubMed PMID: 30049881. DOI: 10.1126/science.aan3975 

Meksiarun P, Aoki PHB, Van Nest SJ, Sobral-Filho RG, Lum JJ, Brolo AG, Jirasek A. Breast cancer subtype specific biochemical responses to radiation. Analyst. 2018 Aug 6;143(16):3850-3858. PubMed PMID: 30004539. DOI: 10.1039/c8an00345a


MacPherson S, Kilgour M, Lum JJ. Understanding lymphocyte metabolism for use in cancer immunotherapy. FEBS J. 2018 Jul;285(14):2567-2578. Epub 2018 Apr 17. Review. PubMed PMID: 29611301.


Van Nest SJ, Nicholson LM, DeVorkin L, Brolo AG, Lum JJ, Jirasek A. Raman Spectroscopic Signatures Reveal Distinct Biochemical and Temporal Changes in Irradiated Human Breast Adenocarcinoma Xenografts. Radiat Res. 2018. May;189(5):497-504. Epub 2018 Feb 23. PubMed PMID:29474157.


Sobral-Filho RG, DeVorkin L, Macpherson S, Jirasek A, Lum JJ, Brolo AG. Ex Vivo Detection of Circulating Tumor Cells from Whole Blood by Direct Nano particle Visualization. ACS Nano. 2018 Feb 27;12(2):1902-1909. Epub 2018 Feb 7. PubMed PMID: 29401387.


Joe MB, Lum JJ, Watson PH, Tonseth RP, McGhie JP, Truong PT. Radiation generates an abscopal response and complete resolution of metastatic squamous cell carcinoma of the anal canal: a case report. J Gastrointest Oncol. 2017 Dec;8(6):E84-E89. PubMed PMID: 29299375; PubMedCentral PMCID: PMC5750188. DOI: 10.21037/jgo.2017.06.15


Kalina JL, Neilson DS, Lin YY, Hamilton PT, Comber AP, Loy EMH, Sahinalp SC,Collins CC, Hach F, Lum JJ. Mutational Analysis of Gene Fusions Predicts Novel MHC Class I-Restricted T-Cell Epitopes and Immune Signatures in a Subset of Prostate Cancer. Clin Cancer Res. 2017 Dec 15;23(24):7596-7607. doi:10.1158/1078-0432.CCR-17-0618. Epub 2017 Sep 27. PubMed PMID: 28954787; PubMedCentral PMCID: PMC5831673.

MacPherson S, Horkoff M, Gravel C, Hoffmann T, Zuber J, Lum JJ. STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth. Cell Rep. 2017 May 2;19(5):910-918. doi:10.1016/j.celrep.2017.04.012. PubMed PMID: 28467904.


Sobral-Filho RG, Brito-Silva AM, Isabelle M, Jirasek A, Lum JJ, Brolo AG. Plasmonic labeling of subcellular compartments in cancer cells: multiplexing withfine-tuned gold and silver nanoshells. Chem Sci. 2017 Apr 1;8(4):3038-3046. doi:10.1039/c6sc04127b. Epub 2017 Feb 3. PubMed PMID: 28451372; PubMed Central PMCID:PMC5380877.

DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM, Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma. Mol Cancer Res. 2017 Mar;15(3):250-258. doi: 10.1158/1541-7786.MCR-16-0132. Epub 2017 Feb 9. PubMedPMID: 28184014; PubMed Central PMCID: PMC5451253.

Kalina JL, Neilson DS, Comber AP, Rauw JM, Alexander AS, Vergidis J, Lum JJ. Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications forProstate Cancer Immunotherapy. Cancers (Basel). 2017 Jan 27;9(2). pii: E13. doi:10.3390/cancers9020013. Review. PubMed PMID: 28134800; PubMed Central PMCID:PMC5332936.



Harder SJ, Isabelle M, DeVorkin L, Smazynski J, Beckham W, Brolo AG, Lum JJ, Jirasek A. Raman spectroscopy identifies radiation response in human non-small cell lung cancer xenografts. Sci Rep 2016 Feb 17;6:21006. doi:10.1038/srep21006. PubMed PMID: 26883914; PubMed Central PMCID: PMC4756358.

Klionsky DJ,  et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez,Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.


Lebovitz CB, DeVorkin L, Bosc D, Rothe K, Singh J, Bally M, Jiang X, YoungRN, Lum JJ, Gorski SM. Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines? Autophagy. 2015;11(10):1949-52. doi: 10.1080/15548627.2015.1078962. PubMed PMID:26506897; PubMed Central PMCID: PMC4824567.


Matthews Q, Isabelle M, Harder SJ, Smazynski J, Beckham W, Brolo AG, Jirasek A, Lum JJ. Radiation-Induced Glycogen Accumulation Detected by Single Cell Raman Spectroscopy Is Associated with Radioresistance that Can Be Reversed by Metformin. PLoS One. 2015 Aug 17;10(8):e0135356. doi:10.1371/journal.pone.0135356. eCollection 2015. PubMed PMID: 26280348; PubMedCentral PMCID: PMC4539228.


Schlie K, Westerback A, DeVorkin L, Hughson LR, Brandon JM, MacPherson S,Gadawski I, Townsend KN, Poon VI, Elrick MA, Côté HC, Abraham N, Wherry EJ, Mizushima N, Lum JJ. Survival of effector CD8+ T cells during influenza infection is dependent on autophagy. J Immunol. 2015 May 1;194(9):4277-86. doi:10.4049/jimmunol.1402571. Epub 2015 Apr 1. PubMed PMID: 25833396.


Harder SJ, Matthews Q, Isabelle M, Brolo AG, Lum JJ, Jirasek A. A Raman spectroscopic study of cell response to clinical doses of ionizing radiation. Appl Spectrosc. 2015;69(2):193-204. doi: 10.1366/14-07561. Epub 2015 Jan 1.PubMed PMID: 25588147.


Johnson LD, Nesslinger NJ, Blood PA, Chima N, Richier LR, Ludgate C, Pai HH, Lim JT, Nelson BH, Vlachaki MT, Lum JJ. Tumor-associated autoantibodies correlate with poor outcome in prostate cancer patients treated with androgen deprivation and external beam radiation therapy. Oncoimmunology. 2014 Jun 25;3:e29243. eCollection 2014. PubMed PMID: 25114831; PubMed Central PMCID: PMC4125379.


Neilson D, MacPherson S, Townsend KN, Lum JJ. Tumor vascularity in ovarian cancer: T cells need breathing room. Oncoimmunology. 2014 Apr 8;3:e28272.eCollection 2014. PubMed PMID: 25050200; PubMed Central PMCID: PMC4063148.



Townsend KN, Spowart JE, Huwait H, Eshragh S, West NR, Elrick MA, Kalloger SE, Anglesio M, Watson PH, Huntsman DG, Lum JJ. Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma. PLoS One. 2013 Dec 23;8(12):e82406. doi:10.1371/journal.pone.0082406. eCollection 2013. PubMed PMID: 24376535; PubMedCentral PMCID: PMC3871161.


Jardon MA, Rothe K, Bortnik S, Vezenkov L, Jiang X, Young RN, Lum JJ, Gorski SM. Autophagy: from structure to metabolism to therapeutic regulation. Autophagy. 2013 Dec;9(12):2180-2. doi: 10.4161/auto.26378. Epub 2013 Sep 30. PubMed PMID:24201076.



Razavi M, Johnson LD, Lum JJ, Kruppa G, Anderson NL, Pearson TW. Quantification of a proteotypic peptide from protein C inhibitor by liquid chromatography-free SISCAPA-MALDI mass spectrometry: application to identification of recurrence of prostate cancer. Clin Chem. 2013Oct;59(10):1514-22. doi: 10.1373/clinchem. 2012.199786. Epub 2013 Jul 15. PubMedPMID: 23857672.

Spowart JE, Townsend KN, Huwait H, Eshragh S, West NR, Ries JN, Kalloger S,Anglesio M, Gorski SM, Watson PH, Gilks CB, Huntsman DG, Lum JJ. The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer. J Pathol. 2012 Dec;228(4):437-47. doi:10.1002/path.4090. PubMed PMID: 22926683.


Townsend KN, Hughson LR, Schlie K, Poon VI, Westerback A, Lum JJ. Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity. Immunol Rev. 2012 Sep;249(1):176-94. doi: 10.1111/j.1600-065X.2012.01141.x.Review. PubMed PMID: 22889222.


Gorski SM, Ries J, Lum JJ. Targeting autophagy: the Achilles' heel of cancer. Autophagy. 2012 Aug;8(8):1279-80. doi: 10.4161/auto.20828. Epub 2012 Jul 27.PubMed PMID: 22836583.

Hughson LR, Poon VI, Spowart JE, Lum JJ. Implications of therapy-induced selective autophagy on tumor metabolism and survival. Int J Cell Biol. 2012;2012:872091. doi: 10.1155/2012/872091. Epub 2012 Apr 5. PubMed PMID:22550492; PubMed Central PMCID: PMC3328951.


Schlie K, Spowart JE, Hughson LR, Townsend KN, Lum JJ. When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen. Int J Cell Biol. 2011;2011:470597. doi: 10.1155/2011/470597. Epub 2011 Nov 29. PubMed PMID:22190938; PubMed Central PMCID: PMC3235465.


Matthews Q, Jirasek A, Lum JJ, Brolo AG. Biochemical signatures of in vitroradiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy. Phys Med Biol. 2011 Nov 7;56(21):6839-55. doi:10.1088/0031-9155/56/21/006. Epub 2011 Oct 5. PubMed PMID: 21971286.


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