Scott Parks, PhD

I received his B.S.c. with first class honors in Physiology, Cell & Developmental Biology and then his Ph.D. in Cell Physiology from the University of Alberta in the lab of Dr. Greg Goss. After this, I moved to the University of Nice (France) with an NSERC postdoctoral fellowship to work in the lab of Dr. Jacques Pouyssegur. I then obtained a French fellowship to continue his postdoctoral work at the University of Nice, France (La Fondation ARC). Following this I moved to the Monaco Scientific Center (Centre Scientifique de Monaco) where he continued to work as a senior postdoctoral researcher. In 2021, I returned to Canada and joined the Lum lab as a research associate.

Research Associate, University of Victoria

RESEARCH FOCUS

I am an expert in the study of cancer cell physiology with a particular emphasis on cell metabolism, hypoxia, membrane transport, and cellular signaling pathways in the context of nutrient uptake and waste excretion. My current goal is to contribute to the fundamental theme of the Lum lab by elucidating mechanisms of metabolic influence on immune cells in an effort to develop genomically engineered cells for improved cancer immunotherapy.

PUBLICATIONS

(2021)

Cormerais Y, Vucetic M, Parks SK, *Pouyssegur J. (2021) Amino acid transporters are a vital focal point in the control of mTORC1 signaling and cancer. Accepted – Int. J. Mol. Sci. 22 (1), 23.

 

(2020)

Parks SK et al. (2020). Lactate in the cancer microenvironment. Annu. Rev. Cancer Biol. 4: 141-158.

 

(2019)

Guerrini G… Parks SK. (2019). Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells. Biochem. Biophys. Res. Commun. 516(2): 408-413.

Daher B, Parks SK et al. (2019). Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses. Cancer Res. 79(150): 3877-3890.

 

(2018)

Parks SK et al. (2018). AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3-kinase activity. BMC Cancer 18:249.

Cormerais Y,…*Parks SK, *Pouyssegur J. (2018). The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the AA transporter LAT1 (SLC7A5). J. Biol. Chem. 293: 2877-2887 (*co-senior authors).

Zdralevic M…, Parks SK, Pouyssegur J. (2018). Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death. Adv. Biol. Regul. 68: 55-63. 

 

(2017)

Vucetic M, Cormerais Y, Parks SK, Pouyssegur J. (2017). The central role of amino acids in cancer redox homeostasis: vulnerability points of the cancer redox code. Front. Oncol 7:319.

Zdralevic M… Parks SK, Pouyssegur J. (2017). Metabolic plasticity in cancers – distinct role of the genetic disruption of glycolytic enzymes GPI, LDHs or MCTs.  Front. Oncol 7:313.

Parks SK, Pouyssegur J. (2017). Targeting pH regulating proteins for cancer therapy – progress and limitations. Semin. Cancer Biol. 43: 66-73.

Parks SK, Cormerais Y, Pouyssegur J. (2017). Hypoxia and cellular metabolism in tumour pathophysiology. J. Physiol. 595(8): 2439-2450.

Parks SK, Cormerais Y, Durivault J, Pouysségur J. (2017). Genetic disruption of the pHi-regulating Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. Oncotarget 8(6): 10225-10237.  

 

(2016)

Cormerais Y,…Parks SK, Pouyssegur J. (2016). Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth. Cancer Res. 76(15); 4481–92.

Parks SK, Cormerais Y, Marchiq I, Pouysségur J. (2016). Hypoxia optimizes tumour growth by controlling nutrient import and acidic metabolite export. Mol. Asp. Med. 47-48: 3-14.

 

(2015)

Parks SK, Pouyssegur J. (2015). The Na+/HCO3- co-transporter SLC4A4 plays a role in growth and migration of colon and breast cancer cells. J. Cell. Physiol. 230: 1954-1963.

Pettersen EO… Parks SK, et al. (2015). Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. J. Enzyme Inhib. Med. Chem. 30(5):689-721.

 

(2014)

Doyen J… Parks SK,  et al. (2014). Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome. Biochem. Biophys. Res. Com. 451:54-61.

 

(2013)

Parks SK, Chiche J, Pouyssegur J. (2013). Disrupting proton dynamics and energy metabolism for cancer therapy. Nature Reviews Cancer, 13:611-623.

Parks SK et al. (2013). Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J. Cell. Physiol. 228: 1854-1862.

Grosso S, Doyen J, Parks SK, et al. (2013). miR-210 promotes a hypoxic phenotype and increases  radioresistance in human lung cancer cell lines. Cell Death Dis. Mar 14;4:e544.

Doyen J, Parks SK et al. (2013). Knock-down of hypoxia-induced carbonic anhydrases IX and XII radio-sensitizes tumor cells by increasing intracellular acidosis. Front. Oncol. Jan 7;2:199.

 

(2012)

Leccia N et al. (2012). Pseudo-tumor of the scrotum, a rare clinical presentation of dirofilariasis: a report of two autochtonous cases due to Dirofilaria repens. Pathog. Glob. Health. 106:370-372.

Doyen J…Parks SK, et al. (2012). Circulating tumor cells in prostate cancer: a potential surrogate marker of survival. Crit. Rev. Oncol. Hematol. 81: 241-256.

 

(2011)

Parks SK et al. (2011). pH control mechanisms of tumor survival and growth. J. Cell. Physiol. 266: 299-308.

 

(2010)

Parks SK et al. (2010). Intracellular pH regulation in isolated trout gill mitochondrion-rich (MR) cell subtypes: evidence for Na+/H+ activity. Comp. Biochem. Physiol.A.155:139-145.

Tresguerres M, Parks SK et al. (2010). Bicarbonate-sensing soluble Adenylyl Cyclase is an essential sensor for acid-base homeostasis. PNAS. 107: 442-447.

Li G, Parks SK, Goss GG, Chang JP. (2010). PKC mediates GnRH activation of a Na+/H+ exchanger in goldfish somatotropes. Gen. Comp. Endocrinol. 166: 296-306.

 

(2009)

Onken H, Parks SK, Goss GG, Moffett DF. (2009). Serotonin-induced high intracellular pH aids in alkali secretion in the anterior midgut of larval yellow fever mosquito Aedes aegypti L. J. Exp. Biol. 212: 2571-2578.

Parks SK, Tresguerres M, Goss GG. (2009). Cellular mechanisms of Cl- transport in trout gill mitochondrion-rich (MR) cells. Am. J. Physiol. Regul. Integr. Comp. Physiol 296: R1161-R1169.

Chang JP… Parks SK et al. (2009).  Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts – studies on the goldfish model. Gen. Comp. Endocrinol. 161: 42-52.

 

(2008)

Parks SK, Tresguerres M, Goss GG. (2008).  Theoretical considerations underlying Na+ uptake mechanisms in freshwater fishes. Comp. Biochem. Physiol. C. 148: 411-418.

1Tresguerres M, 1Parks SK et al. (2008). Regulation of ion transport by pH and [HCO3-] in isolated gills of the crab Neohelice (Chasmagnathus) granulata. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R1033-R1043. (1Co-first author publication).

 

(2007)

Parks SK, Tresguerres M, Goss GG. (2007). Blood and gill responses to HCl infusions in the Pacific hagfish (Eptatretus stoutii). Can. J. Zool. 85: 855-862.

Tresguerres M, 1Parks SK, Goss GG. (2007). Recovery from blood alkalosis in the Pacific hagfish
(Eptatretus stoutii): involvement of gill V-H+-ATPase and Na+/K+-ATPase. Comp. Biochem. Physiol. A. 148: 133-141. (1Co-first author publication).

Tresguerres M, Parks SK, Wood CM, Goss GG. (2007). V-H+-ATPase translocation during blood alkalosis in dogfish gills: interaction with carbonic anhydrase and involvement in the post-feeding alkaline tide. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292: R2012-R2019.

Parks SK, Tresguerres M, Goss GG. (2007). Interactions between Na+ channels and Na+/HCO3- cotransporters in the freshwater fish gill MR cell: a model for transepithelial Na+ uptake. Am. J. Physiol. Cell Physiol. 292: C935-C944.

 

(2006)

Tresguerres M, Parks SK, Goss GG. (2006). V-H+-ATPase, Na+/K+-ATPase and NHE2 immunoreactivity in the gill epithelium of the Pacific hagfish (Eptatretus stoutii). Comp. Biochem. Physiol. A. 145: 312-321.

Tresguerres M, Orr E, Katoh F, Parks SK, Goss GG. (2006). Chloride uptake and base secretion in freshwater fish: a transepithelial ion transport metabolon? Physiol. Biochem. Zool. 79: 981-996.

Tresguerres M, Parks SK et al. (2006). Microtubule-dependent relocation of branchial V-H+-ATPase to the basolateral membrane in the Pacific spiny dogfish (Squalus acanthias): a role in base secretion.  J. Exp. Biol. 209: 599-609